The March 10 episode of Best Medicine delivered one of its most intense hours yet. Episode 10, titled “Port Wenn-ings and a Funeral,” saw Dr. Martin Best (Josh Charles) face a medical mystery, a sudden death in the community, and a life-or-death emergency that forced him to confront his deepest fear. The episode ended with a major moment between Martin and Louisa Gavin (Abigail Spencer), though it came with complications.
A Routine Visit Uncovers Strange Symptoms
The episode began when Martin was called to examine Agnes Kloofs (Blair Ross), a wealthy but eccentric resident of Port Wenn. Agnes complained of stomach pain, a common enough issue for the town doctor. But during the consultation, Martin noticed something more troubling. Agnes appeared mentally disoriented. Her thoughts wandered, and she struggled to stay focused .
Martin suspected the stomach pain was not the only problem. He recognized that her confusion pointed to a deeper medical issue. Before he could investigate further, the town’s annual bird migration watch took over the day’s events .
Martin rarely attended these community gatherings. He disliked crowds and small talk. But this year was different. Louisa planned to attend, and Martin invited her. Both tried to frame it as a casual meet-up, but their body language made it clear this was meant to be something closer to a date .
A Fatal Fall During the Bird Watch
The bird-watching hike quickly turned into a crowded affair. More and more townspeople joined, leaving Martin and Louisa with little time alone. Peter (Ben Lewis Dougherty), the young boy who often follows Martin, also tagged along, interrupting any chance at romance .
Then Agnes spotted something in the sky. She became convinced she had seen the rare Golden Winged Garbler. Excited and rambling, she joked about being sprinkled with fairy dust like Peter Pan. Without thinking about the danger, she ran after the bird. The chase took her close to a cliff edge. In her confused state, she misstepped and fell to her death .
The sudden accident shocked the entire community. The town entered a long memorial period with multiple events honoring Agnes. But the tragedy also triggered anger in Aunt Sarah (Annie Potts). She had spent years caring for the Kloof sisters and expected to be acknowledged in Agnes’s will. Instead, she received nothing. To make matters worse, Agnes left Sarah in charge of organizing an entire week of memorial celebrations. Sarah felt used and unappreciated, and Martin had to support his aunt through her fury .
Martin Uncovers the Real Cause: Arsenic Poisoning
As the town mourned, Martin could not stop thinking about the symptoms he had seen in Agnes. The stomach pain and mental confusion did not add up. His instincts told him something was medically wrong .
He returned to the Kloof house to investigate. The building had recently suffered storm damage, disturbing parts of the structure. Martin discovered that old interior wallpaper, sealed away for decades, contained arsenic. Once the storm damaged the walls, the toxic material began leaking into the air inside the home .
Exposure to arsenic can cause stomach pain, neurological symptoms, hallucinations, and irrational behavior. Agnes had been slowly poisoned in her own house. The discovery also explained something else. Agnes and her sister had both claimed to see the rare Golden Winged Garbler. Given the hallucination symptoms linked to arsenic, those sightings may not have been real at all .
Emergency Surgery in an Ambulance
While the town dealt with Agnes’s death, another crisis unfolded. Peter had been complaining of pain for a while, but people around him had started dismissing his symptoms. Even Martin had grown used to the boy’s frequent complaints .
Then Peter collapsed. He had suffered a ruptured spleen, a life-threatening injury causing severe internal bleeding. An EMT rushed him into an ambulance, but the situation worsened quickly. The EMT failed to recognize how serious the bleeding was. Martin realized the boy might not survive the trip to the hospital .
There was only one option. Martin had to operate right there in the ambulance.
This moment was terrifying for Martin. He suffers from hemophobia, a severe fear of blood. The condition is exactly why he left his surgical career in Boston and moved to Port Wenn. Now he was being forced to confront that fear in the tightest, most stressful setting imaginable .
Louisa was present during the crisis. She understands Martin’s phobia better than anyone. Instead of panicking, she helped ground him. She reminded him of who he was and what he was capable of doing. With limited tools inside the ambulance, Martin cut into Peter to stop the bleeding until they reached the hospital. Despite the psychological struggle, his movements were precise and confident. He was once an extremely skilled surgeon, and that training took over .
Peter survived.
The Kiss and the Retreat
After the emergency ended, Louisa praised Martin for what he had done. She told him how impressive it was. Without a second thought, Martin kissed her. Louisa kissed him back, confirming what both had been feeling all season .
But the happiness did not last. Martin immediately retreated emotionally. He awkwardly suggested the kiss happened only because of adrenaline. Louisa was visibly hurt. What should have been a romantic breakthrough became another frustrating step backward .
Episode 10 of Best Medicine packed multiple storylines into one intense hour. It began with Martin treating an elderly woman suffering from stomach pain and confusion. Her strange behavior led to a fatal accident during the town’s bird migration event. Martin later discovered the real cause was arsenic poisoning from damaged wallpaper in her own home. Then the episode shifted to Peter’s ruptured spleen and Martin performing emergency surgery inside an ambulance despite his fear of blood. The crisis pushed Martin and Louisa closer, leading to their first kiss, though Martin’s hesitation immediately complicated their relationship again.
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Best Medicine Episode 11 Release Date and What to Expect
Fans eager for the next episode will have to wait a little longer. Fox is taking a one-week break. Best Medicine will not air a new episode on March 17. Instead, Episode 11 is scheduled to return on Tuesday, March 24, 2026, in the show’s regular 8 p.m. ET time slot .
The upcoming episode is titled “Mind Your Own Buboes.” According to Fox’s official description, the episode will feature Martin dealing with a patient who has a mysterious skin condition. Meanwhile, Louisa faces new challenges at the school, and Aunt Sarah’s anger over the will situation may continue to simmer .
The show has already been renewed for a second season, so fans can expect more stories from Port Wenn beyond this season .
For now, viewers are left processing the emotional fallout from Episode 10. Martin saved a boy’s life and finally kissed Louisa, but his inability to process his emotions threatens to undo the progress. The March 24 episode will likely explore where Martin and Louisa go from here.
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