The Fox medical dramedy Best Medicine has been a steady presence on Tuesday nights since its January 2026 premiere. With the show recently picked up for a second season, viewers are now looking for answers about the remaining episodes of Season 1. The series starring Josh Charles as the grumpy Dr. Martin Best took a brief pause in its release schedule, leaving fans wondering when Episode 12 will arrive and what to expect from the season’s final stretch.
Why Best Medicine Took a Short Break
The show follows a weekly release pattern on Fox, with new episodes airing Tuesdays at 8:00 PM ET/PT. After Episode 10, which aired on March 10, 2026, the network took a short break in the schedule. This is a common practice for broadcast television, allowing room for other programming and giving production schedules some breathing room.
Episode 11, titled “Mind Your Own Buboes,” arrived on March 24, 2026. The episode put Port Wenn on lockdown after a patient with fleas sparked fears of a plague outbreak. Martin also had to deal with town gossip surrounding him and Louisa, while Aunt Sarah faced her own personal conflicts with Greg and George.
Best Medicine Episode 12 Release Date and Time
Best Medicine Episode 12 is scheduled to air on Tuesday, March 31, 2026, at 8:00 PM ET/PT on Fox. The episode is titled “A Tale of Two Sister Cities.” This marks the second-to-last episode of Season 1, with the season finale following a week later.
For viewers in different time zones:
- Eastern Time (ET): 8:00 PM
- Central Time (CT): 7:00 PM
- Mountain Time (MT): 6:00 PM
- Pacific Time (PT): 5:00 PM
Streaming Details for Episode 12
If you cannot catch the episode live on Fox, streaming options are available. New episodes become available on Hulu the following day, which means Episode 12 will be on the platform starting Wednesday, April 1, 2026. A standard Hulu subscription starts at $11.99 per month, and the service offers a free trial for new subscribers in most regions.
For viewers outside the United States, availability may vary. The show is distributed by FOX Entertainment Global, but specific international release dates and platforms have not been confirmed. Canadian viewers can typically find Fox programming on Citytv or through the Fox channel on cable packages. Australian audiences may find the series on Foxtel or streaming services that carry Fox content.
What to Expect in Episode 12
According to preview materials released by Fox, Episode 12 brings an international twist to Port Wenn. The town welcomes a delegation from their sister city in Norway, but Martin remains skeptical about the friendly visitors. The official episode description reveals that Louisa visits a specialist who turns out to be Martin’s ex, adding personal tension to the medical drama.
The episode also features some of the town’s signature quirky subplots. Greg becomes convinced he is pooping little men, while Sheriff Mark Mylow starts showing troubling symptoms that require an intervention. This mix of medical cases and small-town absurdity has been the show’s formula since the beginning.
The Season 1 Finale Is Coming Soon
Following Episode 12, the season finale will air on Tuesday, April 7, 2026. Titled “Norway No How,” the finale will wrap up the storylines introduced in the sister city arc and likely set up developments for the recently announced Season 2.
Best Medicine Season 2 Renewal
On March 2, 2026, Fox officially renewed Best Medicine for a second season consisting of 12 episodes. The renewal came after the show delivered strong numbers for the network. The series premiere reached 12.6 million total multiplatform viewers, and the show ranks among broadcast’s top two highest-rated drama debuts this season among adults 18-49.
“Best Medicine quickly became a breakout for us this season, blending sharp humor with real heart,” said Michael Thorn, President of FOX Television Network, in a statement. “Liz Tuccillo brings a distinctive creative voice to the series, and Josh Charles leads an exceptional cast that audiences have embraced. We, along with Propogate, are excited to build on that momentum in season two.”
The renewal means viewers can expect more of Dr. Martin Best’s grumpy medical practice in Port Wenn for the 2026-2027 television season.
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Catch Up on Previous Episodes
If you have missed any episodes during the season, Hulu currently has all previous episodes available for streaming. The show follows Dr. Martin Best, a brilliant but rude Boston surgeon who moves to the small Maine town of Port Wenn to become a general practitioner. His sharp personality clashes with the locals, and he hides a secret blood phobia that makes his job even harder.
The cast includes Abigail Spencer as Louisa Gavin, the schoolteacher who develops a complicated relationship with Martin; Josh Segarra as Sheriff Mark Mylow; Annie Potts as Martin’s Aunt Sarah; and Cree as Elaine Denton, Martin’s well-meaning but clumsy assistant.
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