George Clooney is open to making a dramatic return to television medicine. The Oscar-winning actor recently said he would gladly join the cast of the HBO Max medical drama The Pitt, setting the stage for a potential reunion with his former ER co-star Noah Wyle. While the idea is exciting to fans and network executives alike, no formal plans are in place.
Clooney’s Enthusiastic Response
During a red carpet interview for his latest Netflix movie, Jay Kelly, George Clooney was asked about the possibility of appearing on The Pitt. His response was immediate and positive.
“I’d do that in a heartbeat,” Clooney told Entertainment Tonight.
He was quick to clarify that he has not spoken to his old friend about a role, expressing respect for Wyle’s leadership on the project. “It is his show. I don’t want to interrupt. But I am deeply proud of him, if I’m allowed to be proud of him,” Clooney said. He has consistently praised the show and Wyle’s work, calling him “the most honorable, talented young man” in a previous interview.
HBO Extends a Welcome
Following Clooney’s public comments, HBO and HBO Max content chief Casey Bloys responded. He confirmed that Clooney would be welcomed on the show, though no real conversations have happened yet.
“Sure, he’s welcome,” Bloys said at a press event in New York. “I don’t know if that was a real conversation or not, but sure.”
This open invitation from the network confirms the interest is mutual, even if it remains in the early, speculative stages.
The Legacy of ER and Fan Hopes
The potential for a Clooney and Wyle reunion has generated significant excitement because of their shared history. Both actors starred on the hit 1990s medical drama ER, which launched Clooney to international stardom. He played the charismatic pediatrician Dr. Doug Ross, while Wyle played the earnest and dedicated medical student-turned-doctor John Carter.
The Pitt shares more than just its star, Noah Wyle, with ER. The new series is also executive produced by former ER executive producer John Wells. The show, which follows the staff at the busy Pittsburgh Trauma Medical Center, was renewed for a second season set to premiere in January 2026.
The idea of Clooney returning to a medical drama has led to hopeful speculation among fans who remember his iconic role. However, for now, his involvement is only a popular topic of discussion rather than a confirmed casting.
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What’s Next for the Show and the Star
While audiences wait to see if Dr. Doug Ross will ever grace the halls of The Pitt, George Clooney remains busy with other projects. In late 2025, he will star in the Noah Baumbach-directed film Jay Kelly. He is also set to produce and star in a new film with Annette Bening, an adaptation of Amy Bloom’s memoir In Love.
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