Dr. Martin Best left his prestigious surgical career in Boston for a simpler life in a tiny Maine village, but the quirky residents of Port Wenn are proving to be anything but simple. Best Medicine, the new FOX medical comedy-drama, had its special advance premiere on January 4, 2026, and made its official series premiere on Tuesday, January 6. The show airs on FOX at 5 p.m. PST/8 p.m. EST. If you missed the live broadcast, here is your complete guide on where to find the show and what to expect from its first season.
What Is Best Medicine About?
Best Medicine is an American adaptation of the popular British series Doc Martin. The story follows Dr. Martin Best, a brilliant but socially awkward surgeon played by Josh Charles. He abruptly leaves his high-pressure job in Boston to become the general practitioner in Port Wenn, Maine, a quiet fishing village where he spent summers as a child.
Martin’s mission for a peaceful life is immediately challenged. Despite his top-tier medical skills, his blunt bedside manner and lack of patience quickly alienate the town’s needy and eccentric residents. What the locals do not know is that Martin is battling a secret: a debilitating new phobia of blood that forced him out of surgery, along with other deep-seated psychological issues. The show’s official description from FOX states:
โAlthough Martin can expertly address any medical ailment or mystery in this idiosyncratic town, heโs really just desperate to be left the hell alone. Instead, he keeps getting dragged right smack into the middle of their personal chaos, feuds and fantasies.โ
The heart of the series is the clash between Martin’s desire for isolation and the town’s insistence on pulling him into its fold, suggesting that the community itself might be the cure he needs.
The Full Best Medicine Episode Schedule for Season 1
New episodes of Best Medicine air every Tuesday at 8 p.m. EST/5 p.m. PST on FOX. The next day, each new episode becomes available for streaming on Hulu.
The first season has a planned midseason break. Here is the release schedule for the first half of the season:
- Episode 1: “Docked” โ Premiered Sunday, January 4, 2026 (Special Advance), and Tuesday, January 6, 2026 (Official Premiere).
- Episode 2: “Bean There Done That” โ Airs Tuesday, January 13, 2026. Martin angers the entire town by canceling Port Wenn’s monthly baked bean supper due to a health concern.
- Episode 3: “Take Me Out of the Ballgame” โ Airs Tuesday, January 20, 2026. The town turns against Martin after he accidentally injures their star baseball player.
- Episode 4: “There Might Be Blood” โ Airs Tuesday, January 27, 2026.
- Episode 5: “The Bogfather” โ Airs Tuesday, February 3, 2026.
- Episode 6: “Eyewitness Blues” โ Airs Tuesday, February 10, 2026.
- Episode 7: “Hello Darkness, My Port” โ Airs Tuesday, February 17, 2026.
- Episode 8: “A Tale of Two Sisters” โ Airs Tuesday, February 24, 2026.
Following Episode 8, the show is expected to go on a midseason hiatus. The season is scheduled to resume in March 2026 with Episodes 9 and 10.
Where to Watch Best Medicine: Streaming and Live TV Options
You have several ways to watch Best Medicine, whether you prefer live television or on-demand streaming.
Streaming on Hulu (Next-Day)
The primary streaming home for Best Medicine is Hulu. New episodes are available to stream on the Hulu platform the day after they air on FOX. This applies to both Hulu’s on-demand library and its live TV subscription service.
Watching Live on FOX
You can watch new episodes live as they broadcast. This can be done through:
- A traditional cable or satellite TV subscription that includes FOX.
- A live TV streaming service that carries FOX in its channel lineup, such as Hulu + Live TV, YouTube TV, or FuboTV.
FOX’s Official Platforms
FOX also offers its own streaming option called FOX One. This service provides access to FOX programming. You can check the FOX website or app for details on how to watch through this platform.
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Main Cast and Characters of the FOX Series
The show features a mix of seasoned network TV actors and fresh faces who bring the town of Port Wenn to life.
- Josh Charles as Dr. Martin Best: The brilliant, rude, and phobia-ridden surgeon at the center of the story.
- Abigail Spencer as Louisa Glassman: The charming and persistent local schoolteacher who becomes Martin’s primary love interest and strives to break through his tough exterior.
- Annie Potts as Aunt Sarah: Martin’s sassy aunt, a lobster fisherwoman who provides him with a place to stay and blunt advice.
- Josh Segarra as Sheriff Mark Mylow: The good-natured town sheriff who is navigating single life.
- Cree as Elaine Denton: Martin’s young, energetic, and often distracted office assistant who is more focused on building her YouTube influencer career than on filing medical charts.
The series is adapted from the British Doc Martin by an executive production team that includes Ben Silverman (The Office U.S. version) and producers from the original British series.
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